Can oxygen therapy cheat aging? Bryan Johnson makes 'bizarre' claim after 90-day experiment

Bryan Johnson is not ready to desert his ‘immortal’ dream and his quest to ‘live forever’!

The American entrepreneur, venture capitalist, who has become widely known as a biohacker, has recently claimed that a 90-day regimen of hyperbaric oxygen therapy (HBOT) has significantly reversed his biological age, giving him the "biology of a 10-year-old."

This assertion is part of Johnson's broader quest to halt or even reverse aging, a mission he pursues through his venture, Blueprint. The experiment involved daily sessions in a pressurized chamber, breathing 95-100% pure oxygen, aiming to enhance tissue repair and rejuvenation.


What is Hyperbaric Oxygen Therapy (HBOT)?

HBOT is a medical treatment where individuals breathe pure oxygen in a pressurized chamber. This process increases oxygen levels in the blood, promoting faster healing and reducing inflammation. Under hyperbaric conditions, oxygen dissolves directly into plasma, allowing it to reach deeper tissues and areas with poor circulation. Each session typically lasts 60–120 minutes, depending on the condition being treated.

HBOT is the most effective longevity therapy I’ve done.

Here's what happened. pic.twitter.com/JqMqgKqDbi

— Bryan Johnson (@bryan_johnson) May 29, 2025

But is HBOT all about benefits?

Turns out, it’s not.


What are the potential side effects of this therapy?

Hyperbaric Oxygen Therapy (HBOT) can have several potential side effects, ranging from mild to serious. Most complications are mild and temporary, but the risk of complications increases with longer and repeated therapies. Common side effects include ear pain, sinus pressure, and temporary vision changes. More serious complications, though rare, include lung damage, seizures, and low blood sugar.


Who is Bryan Johnson?

The Silicon Valley entrepreneur turned biohacker, Johnson, has garnered significant attention for his radical approach to anti-aging, known as "Project Blueprint." This initiative involves a stringent regimen of lifestyle modifications, including a strict diet, exercise routine, and the use of various medical treatments. He has invested approximately $2 million annually into this project, aiming to reverse his biological age and achieve optimal health.



Johnson's anti-aging regimen:

Johnson's daily routine is meticulously structured to optimize his physical and mental performance. He begins his day early, consuming a specialized supplement regimen and engaging in various health practices. His diet is plant-based, avoiding sugar and processed foods, and he adheres to strict sleep and exercise protocols. He also utilizes advanced therapies like stem cell injections and HBOT to maintain his body in a youthful state.



Social media reactions to Johnson’s methods:

Johnson's methods have been met with both intrigue and skepticism. His previous experiments, such as blood transfusions from his teenage son, have drawn criticism from medical professionals and ethicists. These practices raise questions about consent, safety, and the potential implications of such interventions.

While some consider his efforts groundbreaking, others question the scientific validity and ethical implications of his approach.

For example, experts acknowledge that HBOT can aid in healing and tissue repair, but its long-term effects on aging are not well-established. Some researchers express skepticism about the extent of age reversal that Johnson claims, emphasizing the need for rigorous, peer-reviewed studies.

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